| 2021-08-14 15:00:0014 August 2021 | Hebburn Town  | 0 - 1 |  Frickley Athletic | NPL East Division | N/A |
| 2021-08-17 19:45:0017 August 2021 | Frickley Athletic | 2 - 1 |  Brighouse Town | NPL East Division | N/A |
| 2021-08-21 15:00:5321 August 2021 | Frickley Athletic | 0 - 3 |  Sunderland RCA | FA Cup | N/A |
| 2021-08-24 19:45:0024 August 2021 | Lincoln United  | 1 - 0 | Frickley Athletic | NPL East Division | N/A |
| 2021-08-28 15:00:0028 August 2021 | Frickley Athletic | 2 - 0 |  Tadcaster Albion AFC | NPL East Division | N/A |
| 2021-08-30 15:00:0030 August 2021 | Worksop Town  | 1 - 2 | Frickley Athletic | NPL East Division | N/A |
| 2021-09-07 19:45:007 September 2021 | Bridlington Town  | P - P | Frickley Athletic | NPL East Division | N/A |
| 2021-09-10 19:45:0010 September 2021 | Frickley Athletic | 0 - 1 |  Ossett United | NPL East Division | N/A |
| 2021-09-14 19:45:0014 September 2021 | Frickley Athletic | 0 - 3 |  Marske United FC | NPL East Division | N/A |
| 2021-09-18 15:00:0018 September 2021 | Dunston  | 6 - 0 | Frickley Athletic | NPL East Division | N/A |
| 2021-09-25 15:00:0025 September 2021 | Frickley Athletic | 1 - 2 |  Pickering Town | NPL East Division | N/A |
| 2021-10-02 15:00:002 October 2021 | Stockton Town  | 1 - 1 | Frickley Athletic | NPL East Division | N/A |
| 2021-10-09 15:00:309 October 2021 | Prescot Cables  | 0 - 2 | Frickley Athletic | FA Trophy | N/A |
| 2021-10-13 19:45:0013 October 2021 | Hallam FC  | 4 - 2 | Frickley Athletic | Sheffield and Hallam Senior Cup | N/A |
| 2021-10-19 19:45:1819 October 2021 | Bridlington Town | 1 - 1 | Frickley Athletic | NPL East Division | N/A |
| 2021-10-23 15:00:0023 October 2021 | Yorkshire Amateur  | 0 - 0 | Frickley Athletic | NPL East Division | N/A |
| 2021-10-30 15:00:5730 October 2021 | Radcliffe FC  | 3 - 1 | Frickley Athletic | FA Trophy | N/A |
| 2021-11-06 15:00:006 November 2021 | Frickley Athletic | 0 - 2 |  Liversedge | NPL East Division | N/A |
| 2021-11-13 15:00:0013 November 2021 | Stocksbridge Park Steels  | 1 - 2 | Frickley Athletic | NPL East Division | N/A |
| 2021-11-20 15:00:0020 November 2021 | Frickley Athletic | 1 - 2 |  Cleethorpes Town | NPL East Division | N/A |
| 2021-12-04 15:00:004 December 2021 | Frickley Athletic | 1 - 1 |  Shildon AFC | NPL East Division | N/A |
| 2021-12-11 15:00:0011 December 2021 | Brighouse Town | 3 - 1 | Frickley Athletic | NPL East Division | N/A |
| 2021-12-18 15:00:0018 December 2021 | Frickley Athletic | 0 - 1 | Hebburn Town | NPL East Division | N/A |
| 2021-12-27 15:00:0027 December 2021 | Pontefract Collieries F C  | 2 - 0 | Frickley Athletic | NPL East Division | N/A |
| 2022-01-01 15:00:001 January 2022 | Frickley Athletic | 0 - 1 | Worksop Town | NPL East Division | N/A |
| 2022-01-08 15:00:008 January 2022 | Frickley Athletic | 0 - 3 | Stockton Town | NPL East Division | N/A |
| 2022-01-29 15:00:0029 January 2022 | Frickley Athletic | 1 - 4 | Yorkshire Amateur | NPL East Division | N/A |
| 2022-02-05 15:00:005 February 2022 | Liversedge | 2 - 0 | Frickley Athletic | NPL East Division | N/A |
| 2022-02-08 19:45:008 February 2022 | Frickley Athletic | 1 - 0 | Stocksbridge Park Steels | NPL East Division | N/A |
| 2022-02-19 15:00:0019 February 2022 | Marske United FC | 4 - 0 | Frickley Athletic | NPL East Division | N/A |
| 2022-02-26 15:00:0026 February 2022 | Frickley Athletic | 1 - 2 | Dunston | NPL East Division | N/A |
| 2022-03-05 15:00:005 March 2022 | Pickering Town | 1 - 2 | Frickley Athletic | NPL East Division | N/A |
| 2022-03-12 15:00:0012 March 2022 | Ossett United | 4 - 2 | Frickley Athletic | NPL East Division | N/A |
| 2022-03-19 15:00:0019 March 2022 | Frickley Athletic | 2 - 0 | Bridlington Town | NPL East Division | N/A |
| 2022-03-22 19:45:0022 March 2022 | Sheffield FC  | 1 - 0 | Frickley Athletic | NPL East Division | N/A |
| 2022-03-26 15:00:0026 March 2022 | Frickley Athletic | 2 - 2 | Sheffield FC | NPL East Division | N/A |
| 2022-04-02 15:00:002 April 2022 | Cleethorpes Town | 3 - 0 | Frickley Athletic | NPL East Division | N/A |
| 2022-04-09 15:00:009 April 2022 | Frickley Athletic | 1 - 4 | Lincoln United | NPL East Division | N/A |
| 2022-04-16 15:00:0016 April 2022 | Tadcaster Albion AFC | 2 - 0 | Frickley Athletic | NPL East Division | N/A |
| 2022-04-18 15:00:0018 April 2022 | Frickley Athletic | 1 - 3 | Pontefract Collieries F C | NPL East Division | N/A |
| 2022-04-23 15:00:0023 April 2022 | Shildon AFC | 2 - 2 | Frickley Athletic | NPL East Division | N/A |
